The role of miRNA in diagnosing and clarifying the pathomechanisms in major depressive disorder

Introduction There are currently no diagnostic or treatment-guiding biomarkers for major depressive disorder (MDD). Microribonucleic acids (miRNA) may facilitate understanding the reorganisation of gene expression networks in MDD. Identifying miRNA and target mRNA pathways that contribute to MDD open new therapeutic avenues, such as inhibiting endogenous administering exogenous miRNA. Objectives This study investigates how miRNAs can clarify molecular mechanisms by comparing levels blood serum patients with healthy individuals. The also discriminative ability distinguish between depressed controls. Methods Sixty were matched 60 controls based on age, gender, ethnicity, years education. severity depression was measured using Hamilton Depression Rating Scale, venous collected profiling. Using QIAGEN Ingenuity Pathway Analysis, constructed identify biological associated influenced differentially expressed miRNAs. Analyses receiver operating characteristic (ROC) performed examine capacity Results Six (miR-542-3p, miR-181b-3p, miR190a-5p, miR-33a-3p, miR-3690, miR-6895-3p) significantly down-regulated untreated compared miR-542-3p has experimentally validated targets predicted be ROC analyses determined a panel containing miR-542-3p, miR181b-3p, miR-3690 distinguished individuals an area under curve value 0.67. Conclusions Specific miRNAs, including implicated pathophysiology depression. They could used accurately Disclosure Interest None Declared